The Dose was retroengineered from schematics un-earthed from the blighted Archology of Saltash. Only a thousand or so of these crystalline pills exist within Spire.
Human scientists believe that fore-runners who came before the young races of the world perfected the medication to remove the need for sleep – one pill would rearrange their brains into a different configuration where it was simply no longer required. The human version available today works, but only for a week or so, at which point the effect of the lost sleep starts to catch up with the user – unless they take another pill. Every serious user of the drug in Spire – which is to say, all five or six or them – would die from withdrawal if they missed even a single Dose.