Between 1868 and 1969, there were thirteen separate fires on the Cuyahoga River, the worst occurring in 1952. It was one of the most polluted watercourses in all of the United States. But the 1969 fire, although not the most damaging, was the one with the most lasting effects. Public outcry over the fire led to the creation of the Clean Water Act, Great Lakes Water Quality Agreement, and the creation of the federal Environmental Protection Agency and the Ohio Environmental Protection Agency (OEPA).
Water quality on the Cuyahoga has improved, and most of the largest individual sources of pollution have been cleaned up, but the problem remains one that needs guarding against to prevent a recurrence.