One of the most addictive and dangerous of steroids, Venom first appeared on the streets of Gotham City early in the self-appointed mission of the Batman. In fact, Batman himself was one of its most prominent users for a time.
Unfortunately, in addition to enhancing strength to a superhuman degree, Venom had a number of side-effects, including muscular dystrophy (when not in use) and a capacity to addict users stronger than most drugs short of crack. Batman quickly realised this, and went cold turkey, a process that took about a month (and which was accompanied by incredible physical pain and vivid hallucinations). He never used the drug again, although villains such as Bane and Lex Luthor did.