Chuckles is the street name of a mixture of Joker Venom and regular ecstasy, created by the crime boos Maxie Zeus. It’s name derives from the ‘giggly’ high it produces.
It quickly became popular in the inner city nightclubs of Gotham City, and like most drugs that this is true of, it spread to the suburbs. As the use of Chuckles spread, its side effects became widespread – including lockjaw, paranoia and psychosis. It becomes considered the worst drug epidemic since crack in the late ’80s. The Joker was infuriated by someone turning his trademark Joker Venom into a recreational drug “rocked at a kegger.”